Molecular Glues:

Reshaping protein surfaces to

induce protein degradation

Our proprietary QuEEN (Quantitative and Engineered Elimination of Neosubstrates) platform encapsulates our team’s deep and growing expert knowledge and discovery capabilities across biology, chemistry, and computational sciences.

Central to our QuEEN platform is a detailed understanding of the molecular interactions promoted by our small molecule MGDs between E3 ligases and therapeutically-relevant proteins, which have been considered undruggable or inadequately drugged.

Learn About QuEEN