A growing catalogue of target proteins identified through our proprietary artificial intelligence approach that enables us to identify degrons for therapeutically relevant proteins
The crown of
Our platform is purpose-built to support the discovery and development of drugs that degrade therapeutically relevant proteins by
systematically identifying therapeutically relevant protein targets that may be amenable to MGD-induced degradation, and
rationally designing molecules that can be optimized towards high potency and selectivity.
Central to our QuEEN platform is a detailed understanding of the molecular interactions promoted by our MGDs between ubiquitin ligases and structural features called degrons on the surface of therapeutically relevant proteins
Degrons are elements on proteins that act as ubiquitin ligase recognition signals for protein degradation by the ubiquitin-proteasome system.
Degron identification using an AI-powered deep neural net
Proprietary MGD Library
Rationally designed diverse and growing library of MGDs
Specialized suite of in vitro and in silico assays to discover, optimize, and advance MGDs as clinical candidates
A diverse and continuously growing chemical library of proprietary, drug-like MGDs, rationally designed based on our expertise in basic glue anatomy
A tailored suite of biochemical, structural biology, cellular, proteomics, and in silico tools that enable the discovery and optimization of MGD product candidates that efficiently recruit degron-containing target proteins, also called neosubstrates, to ubiquitin ligases
We focus on therapeutic targets backed by strong biological and genetic rationale with the goal of discovering and developing novel precision medicines. Our internal discovery programs are focused on therapeutically relevant targets, including those that have been considered undruggable.
Our pipeline of MGDs represents a new approach to selectively eliminate therapeutically relevant proteins in cancer and beyond
NSCLC, SCLC, and other MYC-driven Malignances
Oncology and Neurological Diseases
Oncology / Immunology